abstract：AIMS:There are few data available on the incremental benefits of risk factor modification in type 2 diabetes mellitus (T2DM). We simulated the potential benefits of achieving lower systolic blood pressure (SBP) and LDL-cholesterol targets. METHODS:We used the UKPDS Outcomes Model v2.0 to estimate 10-year event rates f...

journal_title：Journal of diabetes and its complications

authors： Mostafa SA,Coleman RL,Agbaje OF,Gray AM,Holman RR,Bethel MA

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Epigenetics modulated tissue-specific gene expression during the onset of type 1 and type 2 diabetes and their complications. METHODS:We searched the PubMed recent studies about the main epigenetic tags involved in type 1 and type 2 diabetes onset and their clinical complications. PubMed studies about the e...

journal_title：Journal of diabetes and its complications

authors： Sommese L,Benincasa G,Lanza M,Sorriento A,Schiano C,Lucchese R,Alfano R,Nicoletti GF,Napoli C

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:Metabolic Syndrome (MetS) is a cardio-metabolic cluster that confers an increased risk of developing both diabetes and atherosclerotic cardiovascular disease (ASCVD). The mechanisms governing the increased ASCVD risk remains to be elucidated. Moreover, lipidomics poses as an exciting new tool that has potent...

journal_title：Journal of diabetes and its complications

authors： Ramakrishanan N,Denna T,Devaraj S,Adams-Huet B,Jialal I

更新日期：2018-08-01 00:00:00

abstract：AIM:We conducted a systematic review of the use of continuous glucose monitoring (CGM) in older patients, in order to consolidate the growing evidence base in this area. METHODS:Our protocol was registered on PROSPERO (CRD42017068523). We searched SCI Web of Science, Ovid SP MEDLINE and EMBASE from January 2010 to Jun...

journal_title：Journal of diabetes and its complications

authors： Mattishent K,Loke YK

更新日期：2018-08-01 00:00:00

abstract：AIMS:The aim of this study was to evaluate ethnic- and sex-specific associations between DM and hearing impairment. METHODS:For this cross-sectional study using National Health and Nutrition Examination Survey in the U.S. and Korea, the total number of eligible participants included was 7081 in the U.S. and 15,704 in ...

journal_title：Journal of diabetes and its complications

authors： Moon S,Park JH,Yu JM,Choi MK,Yoo HJ

更新日期：2018-07-01 00:00:00

abstract：AIMS:To estimate short-term mortality rates for individuals with type 1 or type 2 diabetes diagnosed before age 20 years from the SEARCH for Diabetes in Youth study. METHODS:We included 8358 individuals newly-diagnosed with type 1 (n = 6840) or type 2 (n = 1518) diabetes from 1/1/2002-12/31/2008. We searched the Natio...

journal_title：Journal of diabetes and its complications

authors： Reynolds K,Saydah SH,Isom S,Divers J,Lawrence JM,Dabelea D,Mayer-Davis EJ,Imperatore G,Bell RA,Hamman RF

更新日期：2018-06-01 00:00:00

abstract：AIM:To characterize the risk uveitis, scleritis or episcleritis in relation to diabetes, glycaemic control, and co-existence of retinopathy. METHODS:Using the Royal College of General Practitioners Research and Surveillance Centre database, we established the prevalence of acute uveitis and scleritis or episcleritis o...

journal_title：Journal of diabetes and its complications

authors： Ansari AS,de Lusignan S,Hinton W,Munro N,Taylor S,McGovern A

更新日期：2018-06-01 00:00:00

abstract：AIMS:To identify how efforts to control the diabetes epidemic and the resulting changes in diabetes mellitus, type II (T2D) incidence and survival have affected the time-trend of T2D prevalence. METHODS:A newly developed method of trend decomposition was applied to a 5% sample of Medicare administrative claims filed b...

journal_title：Journal of diabetes and its complications

authors： Akushevich I,Yashkin AP,Kravchenko J,Fang F,Arbeev K,Sloan F,Yashin AI

更新日期：2018-04-01 00:00:00

abstract：OBJECTIVE:To evaluate the relationship between levels of serum apolipoproteins and the prevalence of cardiovascular autonomic neuropathy (CAN) in type 2 diabetes. METHODS:In total, 3199 individuals with type 2 diabetes were investigated in a cross-sectional study. The diagnosis of CAN was made based on the results of ...

journal_title：Journal of diabetes and its complications

authors： Chung JO,Park SY,Han JH,Cho DH,Chung DJ,Chung MY

更新日期：2018-04-01 00:00:00

abstract：:Diabetes mellitus (DM) is a metabolic disorder of glucose homeostasis caused by insufficient secretion or inadequate action of insulin. Nowadays, the increased morbidity of DM is a worldwide issue. Pancreatic beta cell death plays a key role in the progress of DM, especially Type 1 diabetes (T1D). Traditional biomarke...

journal_title：Journal of diabetes and its complications

authors： Liu Y,Tan Q,Liu F

更新日期：2018-03-01 00:00:00

abstract：AIMS:To investigate TAp63 expression in patients with type 2 diabetes mellitus (T2DM) and the potential correlations between TAp63 and proinflammatory cytokines production and other clinical parameters. METHODS:Peripheral blood mononuclear cells (PBMCs) and plasma were collected from 72 T2DM (cases) and 72 healthy sub...

journal_title：Journal of diabetes and its complications

authors： Hu X,Liu J,Sun L,Liu L,Hu Y,Yuan Y,Wu G,Wang Y,Chen J,Xu Y

更新日期：2018-03-01 00:00:00

abstract：AIMS:Metformin treatment is associated with a decrease of serum vitamin B12, but whether this reflects tissue B12 deficiency is controversial. We studied the effects of metformin on serum levels of methylmalonic acid (MMA), a biomarker for tissue B12 deficiency, and on onset or progression of neuropathy. METHODS:In th...

journal_title：Journal of diabetes and its complications

authors： Out M,Kooy A,Lehert P,Schalkwijk CA,Stehouwer CDA

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:Urinary microRNAs (miRNAs) play a role in the pathogenesis of chronic kidney disease (CKD). AIM:To identify the expression of urinary miR-377 and miR-216a in 50 children and adolescents with type 1 diabetes (T1DM) compared with 50 healthy controls and assess their relation to the degree of albuminuria, glyc...

journal_title：Journal of diabetes and its complications

authors： El-Samahy MH,Adly AA,Elhenawy YI,Ismail EA,Pessar SA,Mowafy ME,Saad MS,Mohammed HH

更新日期：2018-02-01 00:00:00

abstract：AIMS:This study investigated the association between severe hypoglycemia (SH) and new onset atrial fibrillation (AF) and all-cause mortality in adult patients with type 2 diabetes mellitus (T2DM). METHODS:Retrospective data on patients with T2DM aged between 30 and 75years who received healthcare checkups from January...

journal_title：Journal of diabetes and its complications

authors： Ko SH,Park YM,Yun JS,Cha SA,Choi EK,Han K,Han E,Lee YH,Ahn YB

更新日期：2018-02-01 00:00:00

abstract：AIMS:In the Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes (EMPA-REG) trial, empagliflozin reduced cardiovascular and all-cause mortality in type 2 diabetes (T2D) patients at high cardiovascular risk. We sought to estimate the cost-effectiveness of empagliflozin versus standard treatment for t...

journal_title：Journal of diabetes and its complications

authors： Nguyen E,Coleman CI,Nair S,Weeda ER

更新日期：2018-02-01 00:00:00

abstract：:Incretin based therapies such as dipeptidyl peptidase-4 inhibitors (DPP-4i) and glucagon-like peptide-1 receptor agonists (GLP-1Ra) are increasingly used for the treatment of Type 2 diabetes mellitus. In clinical practice and in previously performed clinical trials, these agents are often used in combination with othe...

journal_title：Journal of diabetes and its complications

authors： Waldrop G,Zhong J,Peters M,Goud A,Chen YH,Davis SN,Mukherjee B,Rajagopalan S

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:The goal of this study was to examine the self-rated health (SRH) of adolescents with type 1 diabetes (T1D). METHODS:A logistic regression analysis of baseline data from adolescents in the United States included in the T1D Exchange Clinic Registry in 2010-2012 was conducted. Participants were 13-18years old...

journal_title：Journal of diabetes and its complications

authors： Abualula NA,Rodan MF,Milligan RA,Jacobsen KH

更新日期：2018-01-01 00:00:00

abstract：:The primary aims of this study have been to explore the diagnostic and prognostic significance of Tissue Doppler parameters (TDI), global longitudinal strain (GLS), and blood pressure (BP) pattern in normotensive diabetic patients. METHODS:The study consisted of 121 diabetic patients and 41 healthy subjects. Conventi...

journal_title：Journal of diabetes and its complications

authors： Stevanovic A,Dekleva M

更新日期：2018-01-01 00:00:00

abstract：AIMS:Several studies have reported that moderately elevated serum uric acid levels are associated with an increased risk of tachyarrhythmias (mainly atrial fibrillation) in patients with and without type 2 diabetes mellitus (T2DM). It is currently unknown whether an association also exists between elevated serum uric a...

journal_title：Journal of diabetes and its complications

authors： Mantovani A,Rigolon R,Pichiri I,Morani G,Bonapace S,Dugo C,Zoppini G,Bonora E,Targher G

更新日期：2017-12-01 00:00:00

abstract：AIM:To examine the trajectory of small artery elasticity (SAE) and pulse pressure (PP) in people with Type 1 diabetes and non-diabetic controls across the lifespan, and explore associations with microvascular complications (CX+). METHODS:This cross-sectional study included 477 Type 1 diabetes patients (188 with CX+, 2...

journal_title：Journal of diabetes and its complications

authors： Benitez-Aguirre PZ,Januszewski AS,Cho YH,Craig ME,Jenkins AJ,Donaghue KC

更新日期：2017-12-01 00:00:00

abstract：AIMS:The pathogenesis of diabetic kidney disease (DKD) is complex and multifactorial; increasing evidence suggests that tubular injury and inflammatory process are involved in disease progression. We investigated the potential association of renal expression of tubular injury markers, neutrophil gelatinase-associated l...

journal_title：Journal of diabetes and its complications

authors： Hwang S,Park J,Kim J,Jang HR,Kwon GY,Huh W,Kim YG,Kim DJ,Oh HY,Lee JE

更新日期：2017-12-01 00:00:00

abstract：AIM:To analyse the OGTT glycemic parameters - fasting, 1h and 2h plasma glucose values singly and in various combinations; with respect to their prediction of future dysglycemia in subjects with normal glucose tolerance (NGT). METHODS:Electronic medical records of individuals who underwent an OGTT between 1991 and 201...

journal_title：Journal of diabetes and its complications

authors： Sai Prasanna N,Amutha A,Pramodkumar TA,Anjana RM,Venkatesan U,Priya M,Pradeepa R,Mohan V

更新日期：2017-11-01 00:00:00

abstract：AIMS:The objective of this study was to evaluate diabetes-related healthcare resource use and associated costs in patients with type 2 diabetes (T2DM) treated with a sulfonylurea (SU), with and without hypoglycemia. METHODS:In this retrospective cohort study, patients 18years or older receiving SU monotherapy or as ad...

journal_title：Journal of diabetes and its complications

authors： Alemayehu B,Liu J,Rajpathak S,Engel SS

更新日期：2017-11-01 00:00:00

abstract：AIMS:Compare performances of diabetes risk scores and glycated hemoglobin (HbA1c) to estimate the risk of incident type 2 diabetes mellitus (T2DM) in Northeast Germany. METHODS:We studied 2916 subjects (20 to 81years) from the Study of Health in Pomerania (SHIP) in a 5-year follow-up period. Diabetes risk scores inclu...

journal_title：Journal of diabetes and its complications

authors： Krabbe CEM,Schipf S,Ittermann T,Dörr M,Nauck M,Chenot JF,Markus MRP,Völzke H

更新日期：2017-11-01 00:00:00

abstract：AIM:A clinical appraisal of existing scientific literature sought to assess the need for long-term prospective epidemiological studies to investigate an increased cancer risk of anti-hyperglycemic medication in type 2 diabetes. METHOD:A focus statement was formulated as: "With a higher risk of cancers in patients with...

journal_title：Journal of diabetes and its complications

authors： Vora J,Ray K,Kosiborod M,Poulter NR,Rajagopalan S,Leiter LA

更新日期：2017-09-01 00:00:00

abstract：BACKGROUND:The proposed mechanisms of impaired wound healing in diabetes involve sustained inflammation, excess oxidative stress and compromised agiogenesis. Hydrogen sulfide (H2S) has been reported to have multiple biological activities. We aim to investigate the role of H2S in impaired wound healing in ob/ob mice and...

journal_title：Journal of diabetes and its complications

authors： Zhao H,Lu S,Chai J,Zhang Y,Ma X,Chen J,Guan Q,Wan M,Liu Y

更新日期：2017-09-01 00:00:00

abstract：AIMS:To assess the association between dipstick hematuria and estimated glomerular filtration rate (eGFR) decline in Japanese patients with type 2 diabetes. METHODS:Longitudinal data were obtained from 3068 Japanese patients with type 2 diabetes. To assess the independent association between dipstick hematuria and eGF...

journal_title：Journal of diabetes and its complications

authors： Mashitani T,Hayashino Y,Okamura S,Kitatani M,Furuya M,Iburi T,Tsujii S,Ishii H,Diabetes Distress and Care Registry at Tenri Study Group.

更新日期：2017-07-01 00:00:00

abstract：AIMS:The Diabetes Complications Severity Index (DCSI) converts diagnostic codes and laboratory results into a 14-level metric quantifying the long-term effects of diabetes on seven body systems. Adoption of the International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) necessitates tran...

journal_title：Journal of diabetes and its complications

authors： Glasheen WP,Renda A,Dong Y

更新日期：2017-06-01 00:00:00

abstract：AIMS:Young adults with type 2 diabetes (T2D, 18-39years) face increased risk of vision loss from diabetic retinopathy (DR). Retinal screening is essential to detect DR, yet screening rates for this group are low and little is known about the underlying factors influencing this important behavior. Using the theoretical ...

journal_title：Journal of diabetes and its complications

authors： Lake AJ,Browne JL,Rees G,Speight J

更新日期：2017-06-01 00:00:00

abstract：AIM:The present study aimed to identify the characteristics of genetically modified pigs carrying a mutant human gene as a research model for diabetes and its complications. METHODS:We developed a transgenic cloned pig (founder, male) carrying a mutant gene, i.e., human HNF-1α (P291fsinsC), which is responsible for ma...

journal_title：Journal of diabetes and its complications

authors： Umeyama K,Nakajima M,Yokoo T,Nagaya M,Nagashima H

更新日期：2017-05-01 00:00:00

abstract：AIMS:We hypothesized that Hispanic/Latino youth at high risk for diabetes would have elevated biomarkers of endothelial dysfunction. METHODS:Among 1316 children 8-16years old from the Study of Latino Youth (SOL Youth), we used Poisson regression to obtain prevalence ratios (PRs) and 95% CIs for the cross-sectional ass...

journal_title：Journal of diabetes and its complications

authors： Parrinello CM,Hua S,Carnethon MR,Gallo LC,Hudson BI,Goldberg RB,Delamater AM,Kaplan RC,Isasi CR

更新日期：2017-05-01 00:00:00

abstract：AIMS:The aim of this study was to compare the changes in the total daily dose (TDD) of insulin of patients on U-500 insulin; before hospitalization, during hospitalization and six weeks after discharge. METHODS:A retrospective chart review of veterans with type 2 diabetes receiving U-500 insulin in the ambulatory sett...

journal_title：Journal of diabetes and its complications

authors： Kedia R,Desouza C,Smith LM,Shivaswamy V

更新日期：2017-05-01 00:00:00

abstract：AIM:The aims of this study are to investigate the relative regulation between miR-126 and VEGF/PI3K/AKT signaling pathway in retinal vascular endothelial cells. METHODS:Rhesus macaque choroid-retinal endothelial cell line (RF/6A) cells were cultured in high glucose to imitate the conditions occurring in DR. First, we ...

journal_title：Journal of diabetes and its complications

authors： Yang WZ,Yang J,Xue LP,Xiao LB,Li Y

更新日期：2017-04-01 00:00:00

abstract：AIM:Investigate contributors to treatment satisfaction in type 1 diabetes (T1D). METHODS:Post-hoc analysis using the Diabetes Treatment Satisfaction Questionnaire status version (DTSQs) in 771 T1D patients from two 28-week trials comparing once-daily insulin glargine 100U/mL (Gla-100) with once- or twice-daily NPH neu...

journal_title：Journal of diabetes and its complications

authors： Polonsky W,Traylor L,Gao L,Wei W,Ameer B,Stuhr A,Vlajnic A

更新日期：2017-03-01 00:00:00

abstract：AIM:The present study evaluates autonomic and somatic nerve function in different stages of glucose tolerance and its correlation with different cardio-metabolic parameters. MATERIAL AND METHODS:Four hundred seventy-eight subjects, mean age 49.3±13.7years and mean BMI 31.0±6.2kg/m2, divided according to glucose tolera...

journal_title：Journal of diabetes and its complications

authors： Dimova R,Tankova T,Guergueltcheva V,Tournev I,Chakarova N,Grozeva G,Dakovska L

更新日期：2017-03-01 00:00:00

abstract：AIMS:The present study investigated the association of serum levels of angiopoietin-related growth factor (AGF) with lower extremity peripheral arterial disease (LEPAD). METHODS:The study group is comprised of 105 patients with lower extremity peripheral arterial disease. The control group consisted of 80 individuals ...

journal_title：Journal of diabetes and its complications

authors： Nie H,Liang Y,Wang HX,Ren HL,Wang YW,Li FD,Zheng YH

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND:Exercise is recommended as a cornerstone of treatment for type 2 diabetes mellitus (T2DM), however, it is often poorly adopted by patients. Even in the absence of apparent cardiovascular disease, persons with T2DM have an impaired ability to carry out maximal and submaximal exercise and these impairments are...

journal_title：Journal of diabetes and its complications

authors： Scalzo RL,Moreau KL,Ozemek C,Herlache L,McMillin S,Gilligan S,Huebschmann AG,Bauer TA,Dorosz J,Reusch JE,Regensteiner JG

更新日期：2017-02-01 00:00:00

abstract：AIMS:Determine the prevalence of glucocorticoid use in U.S. adults with diabetes and whether prevalence is associated with reduced skeletal health, as measured by fracture history and bisphosphonate use. METHODS:Participants were age≥20years from the cross-sectional National Health and Nutrition Examination Survey (19...

journal_title：Journal of diabetes and its complications

authors： Casagrande SS,Cowie CC,Malozowski S

更新日期：2017-02-01 00:00:00

abstract：AIMS:The Japan Diabetes Complications Study (JDCS), a nation-wide, multicenter, prospective study of patients with type 2 diabetes, reported that hemoglobin A1c (HbA1c), systolic blood pressure, and smoking were risk factors for the onset of macroalbuminuria. This study explored the risk factors for glomerular filtrati...

journal_title：Journal of diabetes and its complications

authors： Moriya T,Tanaka S,Sone H,Ishibashi S,Matsunaga S,Ohashi Y,Akanuma Y,Haneda M,Katayama S

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND:miR-126 may increase angiogenesis in patients with diabetic foot ulcers (DFUs) treated with maggot debridement therapy (MDT). METHODS:Real-time quantitative PCR was used to detect expression of miR-126 mRNA in the peripheral blood among the non-diabetic population, type 2 diabetes mellitus patients without ...

journal_title：Journal of diabetes and its complications

authors： Zhang J,Sun XJ,Chen J,Hu ZW,Wang L,Gu DM,Wang AP

更新日期：2017-01-01 00:00:00